CD234 (DARC)-APC, human, REA376, 100 t，130-120-239，美天旎

Clone REA376 recognizes the human CD234 antigen, a multi-pass membrane protein also known as duffy antigen receptor for chemokines (DARC) or Fy glycoprotein (FY). CD234 is responsible for the duffy blood group system and belongs to a family of silent seven-transmembrane spanning receptors, which do not couple to G-proteins and therefore do not transmit intracellular signals like other G-protein–coupled chemokine-receptors leading to integrin activation or cell motility. It binds to a broad range of inflammatory chemokines of both the CC and the CXC chemokine families, but does not interact with homeostatic chemokines. CD234 is expressed on erythrocytes, cerebellar neurons on postcapillary venule, and capillary endothelial cells in a number of peripheral organs including lymph nodes, the lung, and the kidney. In these organs, endothelial CD234 is specifically expressed in the vascular segment involved in leucocyte extravasation. CD234 was shown to mediate chemokine transcytosis from the basolateral to the luminal side of the endothelium, where the chemokines remain immobilized on the tips of endothelial apical microvilli and enhance leucocyte trafficking in vivo.

Additional information: Clone REA376 displays negligible binding to Fc receptors.

Alternative names

ACKR1, CCBP1, WBCQ1, DARC, Dfy, FY, GPD, GpFy