Clone REAL372 is an antibody fragment derived from the full CD48 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.

Clone REAL372 recognizes the human CD48 antigen, a glycosyl-phosphatidyl-inositol (GPI)–anchored cell-surface protein of the CD2 family of molecules which is also known as B-lymphocyte activation marker BLAST-1, BCM1, MEM-102, or SLAM family member 2 (SLAMF2). CD48 is expressed on various hematopoietic cells, and its expression is regulated by viral and bacterial products and immune-associated proteins. CD48 binds CD2 and other molecules, yet its high-affinity ligand in both mouse and human systems is CD244 (2B4). Despite its lack of an intracellular domain, stimulation of CD48 induces rearrangement of signaling factors in lipid rafts, Lck-kinase activity, and tyrosine phosphorylation. As an adhesion and co-stimulatory molecule, CD48 induces numerous effects in B and T lymphocytes, natural killer cells, mast cells, and eosinophils. Some of these depend upon cell-cell interactions via CD244-CD48 binding.

The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

Blast-1, BCM1, MEM-102, SLAMF2, TCT.1

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