CD35 Antibody, anti-human, PE, REAdye_lease™，130-127-121，美天旎

Clone REAL918 is an antibody fragment derived from the full CD35 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.

Clone REAL918 recognizes the human cell surface protein CD35, the C3b/C4b receptor, also known as CR1 or complement receptor type I. CD35 belongs to the complement activation (RCA) family. Four CD35 allotypes with different molecular weights are known; 190, 220, 250 and 280 kDa. CD35 is expressed on hematopoietic cells such as granulocytes, monocytes, B cells, subsets of NK and T cells, erythrocytes, glomerular podocytes and follicular DCs. Known functions of CD35 include transport of C3 complexes on erythrocytes, complement activation, phagocytosis, and inhibition of the activation-induced proliferation of T and B cells.

CR1 has been associated with an increased risk of developing Alzheimer's disease.

For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

CR1, C3BR, C4BR, KN, C3b/C4b-R

Technical specifications