Clone REAL1146 is an antibody fragment derived from the full SPARC antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.

Clone REAL1146 recognizes SPARC, a 43kDa cysteine-rich acidic matrix-associated protein, which is also known as Osteonectin and ON. It is mainly detected in the extracellular compartment. SPARC has different functions. It plays a role in cell differentiation, proliferation and angiogenesis and is involved in tissue remodeling and wound repair. Expression of SPARC is detected in different tissues and organs and has been associated with tumor suppression. A strong expression is found in tissues undergoing morphogenesis and wound repair.

For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Basement-membrane protein 40, BM-40, Osteonectin, ON, Secreted protein acidic and rich in cysteine

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