- 商品介绍
- 规格参数
- 包装参数
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规格 |
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| Accession Number: | AAH07833 |
| Protein Form: | Full Length, Recombinant, Active |
| Shipping Condition: | Dry Ice |
| Molecular Weight: | 82.3 kDa |
| Validated Application: | Kinase Assay |
| Expression System: | Insect |
| KinaseFamily: | PI3 Kinase |
| Protein Length: | Full Length |
| Protein Tag: | GST Tag |
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储存 |
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| Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol |
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描述 |
This PIP5K1A recombinant human protein (full length) was expressed in insect cells. PIP5K1A lipid kinase or phosphatidylinositol-4-phosphate 5-kinase 1 alpha phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP5K1 is required for Wnt3a-induced LRP6 phosphorylation at ser1490 in mammalian cells. Wnt3a stimulates the formation of phosphatidylinositol 4,5-bisphosphates through 'frizzled' and 'dishevelled', the latter of which directly interacts with and activated PIP5KI. PIP5K1A-mediated PIP(2) production is crucial for HIV-1 entry and the early steps of infection in permissive lymphocytes. Overexpression of wild-type PI4P5K1A increases HIV-1 Env-mediated PIP(2) production and enhances viral replication in primary lymphocytes. PIP5K1A recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the Adapta™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
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¥ 44224.19
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¥ 67162.32
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¥ 29724.42
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