Anti-Aiolos-Vio B515, mouse, REA655,100t，130-129-222，美天旎

Clone REA655 recognizes the mouse Aiolos antigen, a member of the Ikaros family of zinc finger transcription factors, also known as IKZF3. The expression is restricted to lymphoid tissues. Aiolos is highly expressed in spleen and mature B cells and at lower levels in thymus and bone marrow. It was first detected in more committed lymphoid progenitors and strongly up-regulated as these differentiate into pre–T and pre–B cell precursors. It is suggested, that the increase of Ikaros and Aiolos in differentiating lymphocytes is essential for normal progression to a mature and immunocompetent state. Aiolos interacts with Ikaros to regulate lymphocyte differentiation.

Additional information: Clone REA655 displays negligible binding to Fc receptors.

IKZF3, Zfpn1a3, Znfn1a3, 5830411O07Rik

Technical specifications