CD87 Antibody, anti-human, Vio® Bright V423, REAfinity™，130-128-654，美天旎

Clone REA892 recognizes the human CD87 antigen, a 36–38 kDa GPI-anchored cell-surface receptor. CD87, also known as uPAR, binds uPA and thus facilitating the catalytic C domain of the uPA to come in close proximity of membrane bound plasminogen. uPA is a serine protease, which converts plasminogen into plasmin which in-turn is involved in digestion of various extracellular matrix proteins. CD87 belongs to the Ly6/neurotoxin receptor family and consists of three disulfide-bonded homologous domains, D1, D2, and D3. Function of uPAR is modulated by two inhibitors, PA1 and PA2. The expression of membrane-bound CD87 is found on granulocytes, monocytes/macrophages, dendritic cells, fibroblasts, endothelial cells, and keratinocytes. Multiple known regulatory functions of CD87 include cell migration, leukocyte adhesion, chemotaxis, signal transduction, and tissue remodeling.

Additional information: Clone REA892 displays negligible binding to Fc receptors.

PLAUR, U-PAR, URKR, uPAR, MO3

Technical specifications