规格
Endotoxin Level:	< 0.1 ng/µg
Form:	Lyophilized
Mass:	20 µg
Product Line:	Gibco®
Protein Form:	Recombinant, Ligand
Research Category:	Immunology, Inflammation, Oncology, Signal Transduction
Shipping Condition:	Approved for shipment on Wet or Dry Ice
Species:	Human
Gene ID (Entrez):	7132
Molecular Weight:	18.3 kDa
Purification Method:	Sequential Chromatography
Purity:	98 %
Protein Subtype:	TNF (Tumor Necrosis Factor)
Gene Alias:	Soluble TNF-RI
Validated Application:	Cell Culture
Protein Family:	Cytokines & Receptors
Expression System:	E. coli

储存
Store in freezer (-5 to -30°C).

描述

Recombinant Human Soluble TNF-Receptor Type I (sTNF-RI) is a bioactive protein intended for use in cell culture applications. sTNF-RI is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor.

• High purity—no interference from other proteins or contaminants
• High biological activity—more results with less protein
• Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High purity recombinant bioactive protein
Recombinant Human Soluble TNF-Receptor Type I is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High biological activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Soluble TNF-Receptor Type I (sTNF-RI) specific activity is determined by measuring the inhibition of TNF-α mediated cytotoxicity in murine L929 cells in the presence of 0.25 ng/ml TNF-α.

Proven compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.

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