规格
|
Accession Number:
|
NP_005246 |
Protein Form:
|
Recombinant, Catalytic |
Shipping Condition:
|
Dry Ice |
Molecular Weight:
|
70.2 kDa |
Validated Application:
|
Kinase Assay |
Expression System:
|
Insect |
KinaseFamily:
|
NAK Kinase Family |
Protein Length:
|
aa 1 - 396 |
Protein Tag:
|
GST Tag |
储存
|
Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
This GAK recombinant human protein (1–396) was expressed in insect cells. GAK serine/threonine kinase or Cyclin-G-associated kinase was originally identified as a protein that is associated with cyclin G. However, neither CDK5 nor GAK kinase activity is activated by cyclin G nor does GAK affect CDK5 kinase activity. GAK seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. GAK recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service