HLA-E Antibody, anti-human, Biotin，130-133-386，美天旎

The 3D12 monoclonal antibody recognizes the human HLA-E protein, a member of the human leukocyte antigen family. HLA-E is a non-classical MHC molecule (MHC-Ib) with limited polymorphisms, which is expressed on the cell surface in a heterodimeric complex with β2-microglobulin. HLA-E is ubiquitously expressed and has a specialized role in NK cell recognition. It binds a restricted set of peptides, e.g., derived from other class I leader sequences. The complex is recognized by NKG2A on NK cells. This recognition protects the HLA-E–expressing cell from NK cell killing. Recently HLA-E recognition by a specialised subset of CD8 T cells has been implicated in pathogen recognition as well as autoimmunity.

QA1, EA1.2, EA2.1, HLA-6.2, MHC, HLA-E

Technical specifications