规格
Accession Number:	NP_001424
Shipping Condition:	Dry Ice
Expression System:	Insect
Protein Form:	Recombinant, Active, Catalytic
Validated Application:	Kinase Assay
Molecular Weight:	84.1 kDa
KinaseFamily:	IRE Family
Protein Length:	aa 468 - end
Protein Tag:	GST Tag

储存
Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

描述

This ERN1 recombinant human protein (468–end) was expressed in insect cells. ERN1 serine/threonine kinase or endoplasmic reticulum to nucleus signaling 1 is the ER to nucleus signaling 1 protein, a human homologue of the yeast Ire1 gene product which possesses intrinsic kinase activity and an endoribonuclease activity and it is important in endoplasmic reticulum-based stress signals. ERN1 controls IRE1 proteolysis in mammalian cells. ERN1 has a critical function in extraembryonic cells that is essential for fetal viability. ERN1 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

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