规格
Accession Number:	NM_032503.2
Assay Entry:	Cell-based beta-arrestin recruitment
Cell Line:	U2OS
Cell State:	Dividing Cells
Cytoplasmic Tail:	Tail from AVPR2 GPCR
Druggable Target:	GPCRs
Gene Symbol:	MCHR2
Human Protein Class:	G-Protein Coupled Receptor (GPCR)
Population Status:	Single Cell Clone Origin
Product Line:	GeneBLAzer®, Tango™
Readout:	End Point
Shipping Condition:	Room Temperature
System Type:	Tango™
Target Entry:	GPR145, MCHR2
Technique:	FRET
Detection Method:	Fluorescent

储存

Contents:
K1836 Tango™ MCHR2-bla U2OS cells
(LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol).
Includes:
• Tango™ MCHR2-bla U2OS cells
• Tango™ MCHR2-bla U2OS Assay Protocol
• Certificate of Analysis

Storage:
The Tango™ MCHR2-bla U2OS cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.

描述

The Tango™ MCHR2-bla U2OS cells contain the human Melanin-concentrating hormone receptor 2 (MCHR2) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line. This parental cell line stably expresses a beta-arrestin⁄TEV protease fusion protein and the beta-lactamase (bla) reporter gene under the control of a UAS response element.

The Tango™ MCHR2-bla U2OS cells are functionally validated for Z' and EC50 concentrations of I-TAC (CXCL11). In addition, Tango™ MCHR2-bla U2OS cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

For Academic pricing please login or contact us at discoverysciences@invitrogen.com.

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