Clone REA522 recognizes the human CD143 antigen, a single-pass type I membrane protein, which is also known as angiotensin-converting enzyme (ACE). CD143, which exists in two isoforms (a 170 kDa somatic form and a 90 kDa germinal form), is part of the renin-angiotensin system (RAS), and increases blood pressure by causing blood vessels to constrict. It is secreted by cells in the endothelium of blood vessels in lungs and kidneys. The function of CD143 is to catalyse the conversion of angiotensin I to angiotensin II, which are also part of RAS. CD143 is highly regulated in different diseases, for example, sarcoidosis, acute hepatits, diabetis mellitus, multiple myeloma, and osteoarthritis. The somatic form is expressed by endothelial cells (especially those of arterioles and lung capillaries), epithelial cells (especially in proximal renal tubules and in the small intestine), by some neuronal cells, and variably on some macrophages and T lymphocytes. The germinal form is expressed by spermatozoa. Furthermore CD143 is expressed by hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues.

Additional information: Clone REA522 displays negligible binding to Fc receptors.

Alternative names

ACE, ACE1, DCP, DCP1, ICH, MVCD3, Kininase II

Technical specifications