THEMIS Antibody, anti-human, Vio® B515, REAfinity™，130-129-197，美天旎

Clone REA463 recognizes the human thymocyte-expressed molecule involved in selection (THEMIS) antigen, a 73 kDa signaling protein, that is also known as thymocyte selection pathway associated (TSEPA), signaling phosphoprotein specific for T cells (SPOT), or GRB2-associated protein (GASP). THEMIS is rapidly tyrosine-phosphorylated upon TCR ligation and is required for the differentiation of immature CD4/CD8 double positive thymocytes into mature CD4 or CD8 single positive thymocytes. It is expressed only in the T cell lineage and is first detected in CD4/CD8 double negative thymocytes, reaching maximum levels at the CD4/CD8 double positive stage. Following thymocyte selection, THEMIS expression is decreased in mature CD4 and CD8 single positive thymocytes and peripheral T cells. Themis^−/− mice show impaired positive selection during thymocyte development and severe reduction of mature thymocytes and peripheral T cells.

Additional information: Clone REA463 displays negligible binding to Fc receptors.

C6orf190, C6orf207, GASP, SPOT, TSEPA, THMS1, GRB2-associated protein

Technical specifications