规格
|
Accession Number:
|
NP_940980.2 |
Kinase Group:
|
Ser⁄Thr Kinases: TKL Group |
Shipping Condition:
|
Dry Ice |
Expression System:
|
Baculovirus |
Form:
|
Frozen |
Protein Form:
|
Catalytic |
Research Category:
|
Drug Development |
Species:
|
Human |
Validated Application:
|
Kinase Assay |
Molecular Weight:
|
205 kDa |
Gene Alias:
|
LRRK2 D1994A |
KinaseFamily:
|
LRRK Kinase Family |
Protein Tag:
|
GST Tag |
储存
|
Kinase proteins are shipped on dry ice and should be stored at -80°C. |
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Certain mutations (e.g. I2020T, G2019S, and R1441C) in this gene have been associated with Parkinson's disease. D1994A is an artificial mutation that renders the kinase catalytically inactive and thus serves as a useful control for activity assays, especially when testing novel substrates.
Related Links:
• LRRK2 tools for advancing Parkinson's disease research
• Kinase protein portfolio
• LanthaScreen® Eu Kinase Binding Assay
• LanthaScreen® Activity Assay