C-peptide Antibody, anti-human, Vio® B515, REAdye_lease™，130-132-037，美天旎

Clone REAL1250 is an antibody fragment derived from the full C-peptide antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.

Clone REAL1250 recognizes the C-peptide polypeptide, also known as connecting peptide, that connects insulin's A-chain to its B-chain in the proinsulin molecule. C-peptide has been shown to bind to the surface of a number of cell types such as neuronal, endothelial, fibroblast and renal tubular, at nanomolar concentrations to a receptor that is likely G-protein-coupled. The signal activates Ca2⁺-dependent intracellular signaling pathways such as MAPK, PLCγ, and PKC, leading to upregulation of a range of transcription factors as well as eNOS and Na⁺K⁺ATPase activities. C-peptide also has been reported to have anti-inflammatory effects as well as aid repair of smooth muscle cells.

For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

connecting peptide, Proinsulin, Insulin

Technical specifications