CD279 (PD-1) Antibody, anti-human, APC, REAdye_lease™，130-122-169，美天旎

Clone REAL531 is an antibody fragment derived from the full CD279 (PD-1) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.

Clone REAL531 recognizes the human CD279 antigen, also known as PD-1 (programmed death-1) or PD1. CD279 is a 55 kDa transmembrane protein belonging to the CD28/CTLA-4 family. It is expressed on T cells, B cells, NK cells, activated myeloid cells, and dendritic cells. CD279 is not expressed on naive T cells but induced after activation and expressed on late, differentiated T cells. The ligands PD-L1 (CD274, also known as B7-H1) and PD-L2 (CD273, also known as B7-DC) belong to the B7 immunglobulin superfamily. PD-1 and its ligands mediate inhibitory signals that regulate the balance between T cell activation, tolerance, and immunopathology.

PD-1 is used as a marker for angioimmunoblastic lymphoma.

For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

PDCD1, PD1, SLEB2, hPD-1, hPD-l, hSLE1

Technical specifications