Clone REAL1031 is an antibody fragment derived from the full VEGFR-3 (FLT-4) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.

Clone REAL1031 recognizes the human VEGFR-3 (FLT-4) antigen, a Single-pass type I membrane protein known as Vascular endothelial growth factor receptor 3, Fms-like tyrosine kinase 4 (FLT-4) or CD310. VEGFR-3 (FLT-4) is a tyrosine-protein kinase that acts as a cell-surface receptor for the vascular endothelial growth factors VEGF-C and VEGF-D. It plays an essential role in adult lymph-angiogenesis, in the development of the vascular network and the cardiovascular system during embryonic development. During early embryogenesis all endothelial cells express VEGFR-3 (FLT-4), while in the adult tissues, VEGFR-3 (FLT-4) expression disappears from the vascular endothelial cells and is observed only on the lymphatic endothelium. VEGFR-3 (FLT-4) plays a major role in tumor growth and metastatic tumor cell dissemination. The receptor is over-expressed on lymphatic vessels in the vicinity of tumors and on the tumor vasculature and therefore may be an excellent target for an effective cancer intervention.

For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

FLT-4, Vascular endothelial growth factor receptor 3, Fms-like tyrosine kinase 4, Tyrosine-protein kinase receptor FLT4, CD310

Technical specifications