TNF-α Antibody, anti-human, PE-Vio® 770, REAfinity™，130-127-531，美天旎

Clone REA656 recognizes the human tumor necrosis factor alpha (TNF-α) antigen, which is a cytokine involved in inflammatory immune responses. TNF-α has different functions, it plays an important role in the regulation of immune cells and is a potent pyrogen causing fever and apoptotic cell death. Furthermore, the TNF intracellular domain form is able to induce interleukin 12 (IL-12) production in dendritic cells. TNF-α is secreted by activated CD4⁺ T cells, monocytes, macrophages, natural killer (NK) cells, mast cells, eosinophils, and neutrophils.

Additional information: Clone REA656 displays negligible binding to Fc receptors.

Tumor necrosis factor, Cachectin, TNF-alpha, TNF-a, DIF-alpha, TNFa, TNFSF2

Technical specifications