规格
Accession Number:	NM_000524
Assay Entry:	Cell-based beta lactamase reporter gene
Cell Line:	CHO-K1
Cell State:	Dividing Cells
Druggable Target:	GPCRs
Gene Symbol:	5HT1A
Population Status:	Single Cell Clone Origin
Product Line:	GeneBLAzer®
Reporter Gene:	BLA (Beta-Lactamase)
System Type:	GeneBLAzer™
Target Entry:	5HT1A, HTR1A
Technique:	FRET
Detection Method:	Fluorescent

储存

Contents:
K1712 GeneBLAzer® 5HT1A Gα15-NFAT-bla CHO-K1 cells
(LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol).
Includes:
• GeneBLAzer® 5HT1A Gα15-NFAT-bla CHO-K1 cells
• GeneBLAzer® 5HT1A Gα15-NFAT-bla CHO-K1 Assay Protocol
• Certificate of Analysis

Storage:
The GeneBLAzer® 5HT1A Gα15 CHO-K1 DA cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.

描述

GeneBLAzer® 5HT1A Gα15-NFAT-bla CHO-K1 cells contain the human 5-HT Receptor 1A (5HT1A) stably integrated into the GeneBLAzer® Gα15-NFAT-bla CHO-K1 cell line. GeneBLAzer® Gα15-NFAT-bla CHO-K1 cells (Cat. no. K1537) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element and the Promiscuous G protein, Gα15.

The GeneBLAzer® 5HT1A Gα15-NFAT-bla CHO-K1 cells are functionally validated for Z' and EC₅₀ concentrations of 5-CT. In addition, GeneBLAzer® 5HT1A Gα15-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

Agonists and antagonists of the 5HT receptors are in various stages of clinical trials for the treatment of neurological disorders like anxiety, insomnia, and depression.

For Academic pricing please login or contact us at discoverysciences@invitrogen.com.

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