CD172g (SIRPγ) Antibody, anti-human, APC-Vio® 770, REAfinity™，130-129-858，美天旎

Clone REA479 recognizes the human CD172g antigen, a single-pass type I membrane protein also known as signal-regulatory protein γ (SIRPγ) or signal-regulatory protein β 2 (SIRPβ2). Signal regulatory proteins (SIRPs) are a family of transmembrane receptor-like signaling proteins that are abundantly expressed in hematopoietic cells, including granulocytes, monocytes, dendritic cells, and lymphocytes. In addition, SIRPs are expressed in neuronal cells and certain types of cancer cells. CD172g is the only member of the SIRP family that is expressed on T cells, some B cells, CD56^bright natural killer (NK) cells, and all activated NK cells. CD172g does bind CD47, albeit with less affinity than CD172a (SIRPα). This interaction mediates cell-cell adhesion, rather than inhibitory signals. The adhesion mediated by contact of CD172g on T cells with CD47 on antigen-presenting cells (APCs) promotes antigen-specific T cell proliferation and costimulates T cell activation.

Additional information: Clone REA479 displays negligible binding to Fc receptors.

SIRPG, SIRP-g, SIRPB2, SIRPgamma

Technical specifications