规格
|
Accession Number:
|
NP_115811 |
Protein Form:
|
Recombinant, Active, Catalytic |
Shipping Condition:
|
Dry Ice |
Molecular Weight:
|
60.5 kDa |
Validated Application:
|
Kinase Assay |
Expression System:
|
Insect |
KinaseFamily:
|
MAP Kinases |
Protein Length:
|
aa 114 - 420 |
Protein Tag:
|
GST Tag |
储存
|
Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
This MLK4 recombinant human protein (114–420) was expressed in insect cells. MLK4 or mixed lineage kinase 4 belongs to the superfamily of MAP kinase kinase kinases (MAP3K1) which contain both ser/thr and tyr kinases activity in their catalytic domains. The structure of this kinase family incorporates an N-terminal Src homology (SH3) domain, followed by the kinase domain, a leucine zipper region, and a CDC42 /RAC -interactive binding (CRIB) motif, but divergent C-terminal regions. MLK4 is highly expressed in kidney and pancreas. MLK4 is a negative regulator of TLR4. MLK4 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service