CD218 (IL-18Rα) Antibody, anti-human, Vio® Bright V423, REAfinity™，130-130-465，美天旎

Clone REA1095 recognizes the CD218 antigen, which is also known as interleukin-18 receptor alpha (IL-18Rα) chain. IL-18 receptor is an heterodimeric receptor complex, and composed of the IL-18Rα chain and the IL-1 receptor accessory protein-like (IL-1RacPL) or IL-18Rβ chain. CD218 represents the ligand-binding chain, whereas IL-18Rβ is suggested to assist in the formation of a high affinity complex and mediates intracellular signals. IL-18R is expressed on a variety of cells including macrophages, neutrophils, natural killer (NK) cells, endothelial, and smooth muscle cells and an upregulated expression is observed on naive T cells, T helper cell type 1 (Tʜ1) cells, and B cells, in the presence IL-12.

Additional information: Clone REA1095 displays negligible binding to Fc receptors.

IL18R1, CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP

Technical specifications