CD230 (PrP) Antibody, anti-human, PE, REAfinity™，130-126-442，美天旎

Clone REA203 recognizes CD230, commonly known as the prion protein (PrP). The normal cellular PrP (PrP^c) is a ubiquitously expressed glycosylphosphatidyl-inositol (GPI) anchored protein. Though the main function of PrP^c remains unknown, it has been suggested that PrP^c may play a role in copper regulation, antioxidant activity, intracellular signaling. PrP^sc is the conformational isoform of PrP^c with similar primary sequence but different tertiary structure and is associated with neurodegenerative diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy, and scrapie in sheeps. PrP^sc is suggested to derive from PrP^c in a posttranslational process which involves PrP^c-PrP^sc molecular interactions.

Additional information: Clone REA203 displays negligible binding to Fc receptors.

PRNP, ASCR, CJD, GSS, KURU, PRIP, PrP, p27-30

Technical specifications