规格
Accession Number:	NP_004963
Assay Entry:	Biochemical terbium phospho-specific activity, Biochemical phospho-specific activity (no antibody)
Kinase Group:	Tyrosine Kinases
Shipping Condition:	Dry Ice
System Compatibility:	LanthaScreen® Antibody, LanthaScreen® Substrate, Zin-LYTE™, Omnia® Bulk Substrate
Target Entry:	JAK2 JH1 JH2 V617F
Target Gene:	Janus kinase 2
Expression System:	Baculovirus
Protein Family:	Kinases & Inhibitors
Protein Form:	Recombinant, Cytoplasmic, Catalytic
Protein Subtype:	Cytoplasmic Tyrosine Kinases
Research Category:	Signal Transduction
Species:	Human
Validated Application:	Kinase Assay
Gene ID (Entrez):	3717
Molecular Weight:	97.9 kDa
Gene Alias:	JAK2 JH1 JH2 V617F
KinaseFamily:	JAK Kinase Family
Protein Length:	aa 532-1132; V617F
Protein Tag:	GST Tag

储存
Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 2 mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

描述

JAK2 is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. This kinase contains both the JH1 (catalytic) and JH2 (pseudokinase) domains of JAK2. The V617F mutation has been shown to be a cause of polycythemia vera.

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