CD134 (OX40) Antibody, anti-rat, PE-Vio® 770, REAfinity™，130-130-426，美天旎

Clone REA540 recognizes the rat CD134 (OX40) antigen, a 50 kDa glycoprotein which is a member of the TNFR superfamily. It contains a typical signal sequence and a single putative transmembrane sequence of 25 predominantly hydrophobic amino acids giving an extracellular domain of 191 amino acids and a cytoplasmic domain of 36 amino acids. The expression of CD134 is restricted to activated rat CD4⁺ T cells and is up-regulated within hours after activation. CD134 and its ligand CD252 (CD134L, OX40L), which is expressed on activated T and B lymphocytes and also a member of the tumor necrosis factor receptor superfamily, were suggested to mediate the interaction between T cells and B cells.

Additional information: Clone REA540 displays negligible binding to Fc receptors.

TNFRSF4, OX-40, Txgp1, MRC OX40

Technical specifications