规格
Accession Number:	NP_004949.1
Kinase Group:	Ser⁄Thr Kinases: Atypical
Shipping Condition:	Dry Ice
System Compatibility:	LanthaScreen® Antibody, LanthaScreen® Substrate, Zin-LYTE™
Target Entry:	mTOR, FRAP1
Target Gene:	FK506 binding protein 12-rapamycin associated protein 1
Expression System:	Baculovirus
Form:	Frozen
Protein Form:	Recombinant, Catalytic
Protein Subtype:	Serine⁄Threonine Kinases
Research Category:	Signal Transduction, Drug Development, Oncology
Species:	Human
Validated Application:	Kinase Assay
Molecular Weight:	163.9 kDa
Gene Alias:	FRAP1 (mTOR)
KinaseFamily:	PIKK Kinase Family
Protein Length:	aa 1360-2549
Protein Tag:	GST Tag

储存
Storage Buffer: 50 mM Tris, pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.1% Polysorbate 20, 2 mM DTT, 50% Glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

描述

FRAP1 (mTOR) is a serine⁄threonine kinase that plays a critical role in cellular growth and proliferation. Perturbations in the mTOR⁄PI3-kinase⁄AKT pathway are associated with numerous forms of cancer. FRAP1 is also the target of rapamycin and its analogues, which are currently used as immunosuppressants and cancer therapeutics.

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