CD1c (BDCA-1) pure, human, REA694, 0,1ml，130-122-298，美天旎

Clone REA694 recognizes the human CD1c antigen, also known as BDCA-1. CD1c is expressed on a major subpopulation of human myeloid dendritic cells (about 0.3% of blood leukocytes). Blood CD1c (BDCA-1)⁺ myeloid dendritic cells are CD11c^high, CD123^low, CD4⁺, Lin^–, CD45RO⁺, CD2⁺, CD16^–, CD141 (BDCA-3)^low, CD303 (BDCA-2)^–, and CD304 (BDCA-4/Neuropilin-1)^–. They express myeloid markers (CD13, CD33) as well as Fc receptors (CD32, CD64, FcεRI) and are of monocytoid appearance. A minor proportion of CD1c (BDCA-1)⁺ myeloid dendritic cells expresses CD14 and CD11b. In blood, CD1c (BDCA-1) is also expressed on a subpopulation of CD19⁺ small resting B lymphocytes. CD1c (BDCA-1) expression has also been detected on cortical thymocytes, on Langerhans cells, and on CD1a⁺ dendritic cells generated ex vivo from monocytes or hematopoietic precursor cells. CD1c (BDCA-1)⁺ myeloid dendritic cells have been designated as type-1 myeloid dendritic cells (MDC1s). The CD1c antigen is a member of the CD1 family of proteins that are structurally related to MHC class I proteins and mediate the presentation of non-peptide antigens to T cells.

Additional information: Clone REA694 displays negligible binding to Fc receptors.

BDCA-1, CD1, R7, M241, T6, CD1a

Technical specifications