规格
Accession Number:	NP_001790, Q130R I NP_001230 I NP_002422
Assay Entry:	Biochemical binding/kinetic, Biochemical ADP accumulation
Kinase Group:	Ser⁄Thr Kinases: CMCG Group
Protein Form:	Full Length, Recombinant
Research Category:	Cell Cycle & Proliferation, DNA Replication & Repair, Signal Transduction
Shipping Condition:	Dry Ice
Species:	Human
System Compatibility:	Adapta™
Target Entry:	CDK7
Target Gene:	cyclin-dependent kinase 7
Gene ID (Entrez):	1022, 1385, 1387, 1390, 4331, 902
Molecular Weight:	43.2⁄42.6⁄40.5 kDa
Quantity:	10μg
Protein Subtype:	Serine⁄Threonine Kinases
Gene Alias:	CDK7/Cyclin H/MNAT1
Validated Application:	Kinase Assay
Protein Family:	Kinases & Inhibitors
Expression System:	Baculovirus
KinaseFamily:	CDK and CHK Kinase Family
Protein Tag:	His Tag

储存
Storage Buffer: 50mM Tris, pH 7.5, 150mM NaCl, 0.5mM EDTA, 0.02% Triton X-100, 2mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

描述

The trimeric complex of CDK7, cyclin H and MNAT1, functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This complex is thought to serve as a direct link between the regulation of transcription and the cell cycle.

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