规格
Accession Number:	NP_005219.2; L861Q
Assay Entry:	Biochemical binding/kinetic, Biochemical terbium phospho-specific activity, Biochemical europium phospho-specific activity
Kinase Group:	Tyrosine Kinases
Mass:	10 µg
Protein Form:	Recombinant, Cytoplasmic
Research Category:	Oncology, Signal Transduction
Shipping Condition:	Dry Ice
Species:	Human
System Compatibility:	LanthaScreen® Antibody, LanthaScreen® Substrate, Zin-LYTE™, Omnia® Bulk Substrate
Tag Position:	N-Terminal
Target Entry:	EGFR L861Q
Target Gene:	Epidermal growth factor receptor
Gene ID (Entrez):	114294, 1956
Molecular Weight:	90.5 kDa
Protein Subtype:	Receptor Tyrosine Kinases
Gene Alias:	EGFR (ErbB1) L861Q
Validated Application:	Kinase Assay
Protein Family:	Kinases & Inhibitors
Expression System:	Baculovirus
KinaseFamily:	EGF Receptor (ErbB) Kinase Family
Protein Length:	aa 668-1210: L858R, aa 668-1210; L861Q
Protein Tag:	GST Tag

储存
Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 2 mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

描述

The epidermal growth factor receptor is a receptor tyrosine kinase that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The EGFR L861Q mutation is an Iressa-responsive mutant observed in the clinic.

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