Siglec-H Antibody, anti-mouse, PerCP-Vio® 700, REAfinity™，130-128-984，美天旎

Clone REA819 recognizes the mouse siglec-H antigen, a 34 kDa transmembrane protein of the Ig superfamily known as mouse sialic acid-binding immunoglobulin-like lectin. Siglec-H is specifically expressed on mouse plasmacytoid dendritic cells, a subset of CD11c⁺ dendritic cells detected at low frequency in all lymphoid tissues, peripheral blood, and some non-lymphoid tissues. Binding of antibodies to siglec-H inhibits type I interferon production, which can be induced in plasmacytoid dendritic cells by DNA and RNA viruses.

Additional information: Clone REA819 displays negligible binding to Fc receptors.

SIGLECH

Technical specifications