PIR-B Antibody, anti-mouse, APC-Vio® 770, REAfinity™，130-130-031，美天旎

Clone REA899 recognizes the B isoform of the mouse paired immunoglobulin-like receptor (PIR-A and PIR-B) antigen, a single-pass type I membrane protein which is also known as leukocyte immunoglobulin-like receptor 3 (LIR-3). Cell surface expression of PIR molecules on myeloid and B lineage cells increase with cellular differentiation and activation. PIR molecules are also expressed on dendritic cells, monocytes/macrophages, and mast cells in varying levels, but not on T cells and NK cells. PIRs functions as receptors for class I MHC antigens. PIR-B down-regulates antigen-induced B cell–activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).

Additional information: Clone REA899 displays negligible binding to Fc receptors.

6M21, Ly89, GP91, LIR-3, LILRB3

Technical specifications