TIM-3 Antibody, anti-mouse, APC-Vio® 770, REAfinity™，130-130-038，美天旎

Clone REA602 reacts with the mouse CD366 (TIM-3) antigen, which is a Tʜ1-specific cell surface protein expressed by differentiated CD4⁺ Tʜ1 and CD8⁺ Tc1 cells and macrophages. It is absent on CD4⁺ Tʜ2 and CD8⁺ Tc2 cells. CD366 (TIM-3) has been proposed to inhibit Tʜ1-mediated immune responses. CD366 (TIM-3) absence enhances the severity of experimental autoimmune encephalomyelitis in mice. The interaction of CD366 (TIM-3) and galectin-9 induces apoptosis of Tʜ1 cells.

Additional information: Clone REA602 displays negligible binding to Fc receptors.

Tim3, CD366

Technical specifications