CD197 (CCR7) Antibody, anti-human, PE-Vio® 615, REAfinity™，130-125-735，美天旎

REA108 recognizes human CD197 which is a chemokine receptor with a C-C motif that mediates homing of T cells to secondary lymphoid organs via high endothelial venules (HEV) and is also known as CCR7. For example, naive T cells migrate very efficiently through lymph nodes using the adhesion molecules L-selectin, CD62L, and CCR7. Ligands for CCR7, e.g. CCL19, are expressed by the HEV of secondary lymphoid organs, by parenchymal cells within T cell zones of lymph nodes, and by endothelial cells at the openings of lymphatic vessels within peripheral tissues. Expression of CCR7 and the CD45RA isoform distinguishes three subsets of T cells: naive T cells (CCR7⁺CD45RA⁺), central memory T cells (CCR7⁺ CD45RA^–), and effector memory T cells (CCR7^– CD45RA^–).

Additional information: Clone REA108 displays negligible binding to Fc receptors.

CCR7, BLR-2, CC-CKR-7, CCR-7, Cdw197, CMKBR7, EBI-1

Technical specifications