Clone REAL831 is an antibody fragment derived from the full Cytokeratin 14 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.

Clone REAL831 recognizes Cytokeratin 14. Cytokeratins, which are found in almost all epithelial cells, are polypeptides with keratin-containing intermediate filaments, which ensure form stability and cohesiveness. Keratins play a critical role in mechanical stability and integrity of epithelial cells and tissues, have regulatory functions and are involved in intracellular signaling pathways. Cytokeratin 14 is a member of the type I keratin family and is mainly found as a heterodimer with type II keratin 5 and forms the cytoskeleton of epithelial cells. It is located in in the basal layer and in the stratum spinosum, stratum granulosum and also expressed in the outer root sheath of anagen follicles and keratinocytes surrounding the club hair during telogen.

For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

KRT14, CK-14, Keratin-14, K14, Cytokeratin-14

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