Notch1 Antibody, anti-human/mouse, PE, REAfinity™，130-124-884，美天旎

Clone REA357 recognizes the human and mouse neurogenic locus notch homolog protein 1 (notch1) antigen, a 300 kDa single-pass type I membrane protein also known as translocation-associated notch protein (TAN-1). Following cleavage in the Golgi, notch forms a heterodimer composed of a 180–200 kDa disulfide-linked extracellular domain (NEXT), and a 120 kDa membrane-bound intracellular portion (NICD). Upon ligand binding the latter is cleaved to form the notch intracellular domain transcription factor. Notch signaling controls cell fate decisions and is involved in multiple cellular differentiation steps during embryonic development and in adult organisms. In the immune system, notch1 plays a non-redundant role for thymic T cell development. Notch1 is also expressed by peripheral T cells and upregulated upon T cell activation. Clone REA357 recognizes the intracellular domain of mouse and human notch1, but not mouse notch2, 3, or 4.

Additional information: Clone REA357 displays negligible binding to Fc receptors.

AOS5, AOVD1, TAN-1, hN1, Mis6, N1, lin-12

Technical specifications