- 商品介绍
- 规格参数
- 包装参数
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规格 |
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| Accession Number: | NP_060895 |
| Shipping Condition: | Dry Ice |
| Expression System: | Insect |
| Protein Form: | Full Length, Recombinant, Active |
| Validated Application: | Kinase Assay |
| Molecular Weight: | 80.3 kDa |
| KinaseFamily: | PI3 Kinase |
| Protein Length: | Full Length |
| Protein Tag: | GST Tag |
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储存 |
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| Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
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描述 |
This PI4K2A (PI4K2 alpha) recombinant human protein (full length) was expressed in insect cells. PI4K2A (PI4K2 alpha) lipid kinase or phosphatidylinositol 4-kinase type 2 alpha is involved in the formation of phosphatidylinositolpolyphosphates (PtdInsPs) which are centrally involved in many biologic processes ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4K2A phosphorylates PtdIns at the D-4 position which is an essential step in the biosynthesis of PtdInsPs. PI4K2A is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. PI4K2A generates PtdIns4P-rich domains within the Golgi which regulate targeting of clathrin adaptor AP-1 complexes. PI4K2A is also required for Wnt to regulate LRP6 phosphorylation. PI4K2A (PI4K2 alpha) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the Adapta™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
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