Clone REA384 recognizes the human T cell immunoglobulin mucin receptor 1 (TIM-1) antigen, a single-pass type I membrane protein also known as hepatitis A virus cellular receptor 1 (HAVcr-1) or kidney injury molecule 1 (KIM-1). TIM-1 is widely expressed, with highest levels in kidney and testis. It is also expressed by activated T cells, B cells, natural killer T cells, and dendritic cells. The TIM gene family is involved in a variety of immunity related processes including T cell proliferation and survival, tissue inflammation, and atopy. In mice, eight TIM genes encode the proteins TIM-1 to TIM-8, whereas only three TIM genes are found in humans encoding TIM-1, TIM-3, and TIM-4. Several lines of evidence suggest that TIM-1 regulates T cell activity in vivo through responses mediated by Tʜ1, Tʜ2, Tʜ17, and regulatory T cells. TIM-1 is recruited to the T cell receptor signaling complex and has a costimulatory role. In addition to serving as a receptor for filoviruses, human TIM-1 is reported to serve as a receptor for hepatitis A virus and a variety of flaviviruses, alphaviruses, and arenaviruses.

Additional information: Clone REA384 displays negligible binding to Fc receptors.

Alternative names

CD365, HAVCR, HAVcr-1, KIM-1, TIMD-1, TIM, TIM1

Technical specifications