CD44v6 Antibody, anti-human, PE-Vio® 615, REAfinity™，130-133-092，美天旎

Clone REA706 recognizes the CD44v6 antigen. CD44 is the receptor for hyaluronic acid (HA), which plays an important role in cell migration, tumor growth, and progression. CD44 is involved in the modification of the activity of receptors including MET and the ERBB family of tyrosine kinases. CD44 is a marker for many types of cancer stem cells (CSC), including breast CSCs that possess higher tumorigenicity and metastatic potential, colorectal, pancreatic, and prostate CSCs. In addition, expression was observed in several cancers as well as on carcinoma cell lines. Here, CD44 plays a role in cancer cell migration and matrix adhesion in response to a cellular microenvironment, thus enhancing cellular aggregation and tumor cell growth. CD44 is also expressed on mesodermal cells, such as hematopoietic, fibroblastic, and glial cells.

Additional information: Clone REA706 displays negligible binding to Fc receptors.

CDw44, Epican, ECMR-III, PGP-I, CSPG9, EMCR III, HCELL, HUTCH-I, H-CAM

Technical specifications