Synaptotagmin Antibody, anti-human, APC, REAdye_lease™，130-132-781，美天旎

Clone REAL1459 is an antibody fragment derived from the full Synaptotagmin antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.

Clone REAL1459 recognizes Synaptotagmin, a family of membrane-trafficking proteins that function as calcium sensors in the regulation of neurotransmitter release and hormone secretion. Mice and humans express 17 synaptotagmin isoforms, where most studies have focused on isoforms 1, 2, and 7, which are involved in synaptic vesicle exocytosis. Synaptotagmins have been shown to regulate exocytosis in other intracellular organelles such as lysosomes, suggesting its role in mediating repair following brain damage by interacting with lysosomes.

For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

SYT

Technical specifications