规格
Accession Number:	NP_002750.1
Assay Entry:	Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group:	Ser⁄Thr Kinases: Other
Shipping Condition:	Dry Ice
System Compatibility:	LanthaScreen® Antibody, LanthaScreen® Substrate
Target Entry:	EIF2AK2
Target Gene:	eukaryotic translation initiation factor 2-alpha kinase 2
Expression System:	Baculovirus
Protein Family:	Kinases & Inhibitors
Protein Form:	Recombinant, Catalytic
Protein Subtype:	Serine⁄Threonine Kinases
Research Category:	Signal Transduction
Species:	Human
Validated Application:	Kinase Assay
Gene ID (Entrez):	9833
Molecular Weight:	62.2 kDa
Gene Alias:	EIF2AK2 (PKR)
KinaseFamily:	PEK Kinase Family
Protein Length:	aa 252-551
Protein Tag:	GST Tag

储存
Storage Buffer: 50 mM Tris, pH 7.5, 50% glycerol, 0.5 mM EDTA, 0.02% Triton X-100, 150 mM NaCl, 2 mM DTT Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

描述

EIF2AK2 (PKR) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses. EIF2AK2 plays a key role in antiviral defense mediated through its direct activation by double-stranded RNA produced by viral infection.

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