CD117 Antibody, anti-human, APC-Vio® 770, REAfinity™，130-111-673，美天旎

Clone REA787 recognizes the human CD117 antigen, also known as c-kit or SCF receptor, which is a 145 kDa receptor tyrosine kinase that is involved in stem cell signaling, activation, and proliferation. The CD117 antigen is expressed on about 1–3% of mononuclear cells from peripheral blood mononuclear cells (PBMCs) or cord blood and on up to 10% of bone marrow cells. CD117 is further expressed on basophils, myeloid dendritic cells, TCRα/β⁺ T cells, CD19⁺ B cells, and CD56⁺ NK cells, as well as on mast cells, melanocytes, and acute myeloid leukemia (AML) blasts. Clone REA787 recognizes a different epitope than clone AC126 and may interfere with SCF-binding. It is therefore not recommended for indirect cell isolation, but is optimal for flow cytometric analysis of cells separated with the CD117 MicroBead Kit, human.

Additional information: Clone REA787 displays negligible binding to Fc receptors.

c-kit, PBT, SCFR, KIT

Technical specifications