- 商品介绍
- 规格参数
- 包装参数
产品介绍
Product Description
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规格 |
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| Accession Number: | NP_005219.2; T790M L858R |
| Form: | Frozen |
| Kinase Group: | Tyrosine Kinases |
| Protein Form: | Cytoplasmic |
| Research Category: | Drug Development |
| Shipping Condition: | Dry Ice |
| Species: | Human |
| Molecular Weight: | 90.6 kDa |
| Gene Alias: | EGFR (ErbB1) T790M L858R |
| Validated Application: | Kinase Assay |
| Expression System: | Baculovirus |
| KinaseFamily: | EGF Receptor (ErbB) Kinase Family |
| Protein Tag: | GST Tag |
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储存 |
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Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Polysorbate 20, 2 mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws. |
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描述 |
The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The double T790M L858R mutant of EGFR displays resistance to Erlotinib (Tarceva) and sensitivity to HKI-272 and rapamycin combination therapy.
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