规格
Accession Number:	NP_066124, V804L
Assay Entry:	Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical europium phospho-specific activity, Biochemical binding/kinetic
Kinase Group:	Tyrosine Kinases
Mass:	10 µg
Protein Form:	Recombinant, Cytoplasmic
Research Category:	Oncology, Signal Transduction
Shipping Condition:	Dry Ice
Species:	Human
System Compatibility:	LanthaScreen® Antibody, LanthaScreen® Substrate, Zin-LYTE™, Omnia® Bulk Substrate
Tag Position:	N-Terminal
Target Entry:	RET V804L
Target Gene:	ret proto-oncogene
Molecular Weight:	79.0 kDa
Protein Subtype:	Receptor Tyrosine Kinases
Gene Alias:	RET V804L
Validated Application:	Kinase Assay
Protein Family:	Kinases & Inhibitors
Expression System:	Baculovirus
KinaseFamily:	RET Kinase Family
Protein Length:	aa 658-1114; V804L
Protein Tag:	GST Tag

储存
Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 2 mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

描述

The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development, and can undergo oncogenic activation by cytogenetic rearrangement. The V804L mutant has been observed in association with cancer.

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