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RET V804E 10UG EA,A33507,赛默飞世尔

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订货号 4BV8771
品牌型号 赛默飞世尔 A33507
货期 询货期
最小订货量 1套
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产品介绍 Product Description
规格
Accession Number: NP_065681.1
Shipping Condition: Dry Ice
Expression System: Insect
Protein Form: Recombinant, Active, Cytoplasmic, Mutant
Validated Application: Kinase Assay
Molecular Weight: 80.5 kDa
KinaseFamily: RET Kinase Family
Protein Length: aa 858 - 1114
Protein Tag: GST Tag
储存
Storage Buffer: 50 mM HEPES pH 7.5, 100 mM NaCl, 5 mM DTT, 15 mM reduced glutathione, 20% glycerol
描述

This RET V804E recombinant human protein (858–1114) was expressed in insect cells. RET receptor tyrosine kinase or ret proto-oncogene is a member of the cadherin superfamily which are cell-surface receptors that transduce signals for cell growth and differentiation. RET can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in the RET gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. RET signaling pathway, by regulating the development of both the nervous and lymphoid system in the gut, plays a key role in the molecular mechanisms that orchestrate intestine organogenesis. RET V804E recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

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