PTK7 (CCK-4) Antibody, anti-human, Vio® Bright V423, REAfinity™，130-130-669，美天旎

Clone REA836 recognizes human protein tyrosine kinase-7 (PTK7). PTK7, also known as colon carcinoma kinase-4 (CCK-4), is a receptor protein tyrosine kinase (RPTK)–like molecule that contains a catalytically inactive tyrosine kinase domain. PTK7 was identified to be important for neural development as a regulator of planar cell polarity, being required for convergent extension movement and neural tube closure. Using the Anti-PTK7 (CCK-4) antibody, PTK7 expression was recently analyzed on blood and bone marrow cells. PTK7 was shown to be expressed on plasmacytoid dendritic cells, CD141 (BDCA-3)^high type-2 myeloid dendritic cells, and CD34⁺ hematopoietic progenitor cells (HPCs). PTK7 was detected on early (CD34⁺ CD133⁺) and late (CD34⁺ CD133^–) HPCs. In tonsils, PTK7 was also found on some T cells.

Additional information: Clone REA836 displays negligible binding to Fc receptors.

CCK-4, CCK4

Technical specifications