Clone REA369 recognizes the mouse CD62E antigen, a single-pass type I membrane glycoprotein also known as E-selectin. CD62E is expressed on endothelial cells and plays a critical role in the recruitment of the appropriate blood cell into specific local sites. It mediates the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with P-selectin glycoprotein ligand 1, which promotes slow rolling and adhesion. CD62E is transcriptionally induced in response to inflammatory cytokines, such as IL-1β and TNFα. It has an important role during hematopoietic stem/progenitor cell trafficking to the bone marrow, and for the maintenance of their quiescent phenotype in vivo. Because selectins are also constitutively expressed in the endothelium of certain tissues such as bone marrow even in the absence of inflammatory stimulation, there has been a growing appreciation that these receptors may be important for tissue homeostasis. Elevated cellular levels of CD62E have been documented in various diseases associated with a pro-inflammatory condition, including diabetes, atherosclerosis, rheumatoid arthritis, and cancer. Conversely, therapeutic strategies, which reduce vascular injury, result in significant down-regulation of CD62E gene expression.

Additional information: Clone REA369 displays negligible binding to Fc receptors.

Alternative names

SELE, E-selectin, ELAM-1, Elam, LECAM2, E-selectin

Technical specifications