规格
|
Assay Entry:
|
Biochemical binding/kinetic |
Kinase Group:
|
Serine/Threonine Kinase |
Target Entry:
|
STK39 (STLK3) |
Species:
|
Human |
Validated Application:
|
Kinase Assay |
Molecular Weight:
|
60.6 kDa |
Gene Alias:
|
STK39, STLK3, DCHT, DKFZp686K05124, PASK, SPAK |
Protein Tag:
|
His Tag |
储存
|
Storage Buffer: 50 mM sodium phosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, 25% glycerol
Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. |
STK39 (STLK3) is involved in the cellular stress response pathway. STK39 is activated in response to hypotonic stress leading to phosphorylation of several cation-chloride-coupled co-transporters. STK39 activates the p38 MAP kinase pathway and its interaction with p38 decreases during cellular stress. STK39 acts as an intermediate in the response to cellular stress. STK39 is also an independent risk factor for hypertension in men and its intragenic SNPs can interact and function in the control of blood pressure. Recombinant full-length human STK39 (STLK3) was expressed using baculovirus in Sf9 insect cells using an N-terminal His tag.
• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use
Related Product:
LanthaScreen® Eu Kinase Binding Assay