规格
Accession Number:	NP_000133; K650E
Assay Entry:	Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group:	Tyrosine Kinases
Mass:	10 µg
Protein Form:	Recombinant, Cytoplasmic
Research Category:	Oncology, Signal Transduction
Shipping Condition:	Dry Ice
Species:	Human
System Compatibility:	LanthaScreen® Antibody, LanthaScreen® Substrate, Zin-LYTE™, Omnia® Bulk Substrate
Tag Position:	N-Terminal
Target Entry:	FGFR3 K650E
Target Gene:	fibroblast growth factor receptor 3
Molecular Weight:	49.8 kDa
Protein Subtype:	Receptor Tyrosine Kinases
Gene Alias:	FGFR3 K650E
Validated Application:	Kinase Assay
Protein Family:	Kinases & Inhibitors
Expression System:	Baculovirus
KinaseFamily:	FGF Receptor Kinase Family
Protein Length:	aa 398-806; K650E
Protein Tag:	His Tag

储存
Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

描述

FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. The K650E mutation leads to constitutive activation and the neonatal lethal disorder TDII.

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