- 商品介绍
- 规格参数
- 包装参数
产品介绍
Product Description
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规格 |
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| Accession Number: | NP_002871, Y340D, Y341D |
| Kinase Group: | Ser⁄Thr Kinases: TKL Group |
| Shipping Condition: | Dry Ice |
| Expression System: | Baculovirus |
| Form: | Frozen |
| Protein Form: | Catalytic |
| Research Category: | Drug Development |
| Species: | Human |
| Validated Application: | Kinase Assay |
| Molecular Weight: | 66.4 kDa |
| Gene Alias: | RAF1 (cRAF) Y340D Y341D |
| KinaseFamily: | RAF Kinase Family |
| Protein Tag: | GST Tag |
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储存 |
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Storage Buffer: 50mM Tris, pH 7.5, 150mM NaCl, 0.5mM EDTA, 0.02% Triton X-100, 2mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws. |
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描述 |
RAF1 (cRAF) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated RAF1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylates and activates the serine⁄threonine specific protein kinases ERK1 and ERK2. The RAF1 Y340D Y341D mutant is constitutively active.
| 长度(mm) | |
| 宽度(mm) | |
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| 重量(kg) |
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